New research from the NMR & Membrane Biophysics Group and colleagues
Researchers from the NMR & Membrane Biophysics Group (University of Melbourne) and the Molecular Assembly Laboratory (RMIT University) have published new research predicting the release profile of small molecules from within the ordered nanostructured lipidic bicontinuous cubic phase, using translational diffusion coefficients determined by PFG-NMR.
The diffusion of amino acids, as models for drugs encapsulated within the lipidic bicontinuous cubic phase, was measured using PFG-NMR. Diffusion of both water and the model drug increased with water channel diameter and the release profiles of the encapsulated amino acids were accurately predicted from the diffusion coefficients using the Higuchi equation.
The research was published in the latest edition of Nanoscale: http://pubs.rsc.org/en/content/articlelanding/2017/nr/c6nr07382d#!divAbstract.
Professor Frances Separovic